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Bu çalışmada, dokuz yeni 3-alkil-4-[3-metoksi-4-(p-nitrobenzoksi)-benzilidenamino]-4,5-dihidro-1H-1,2,4-triazol-5-on (3) bileşiği 3-alkil-4-amino-4,5-dihidro-1H-1,2,4-triazol-5-on (1) bileşiklerinin 3-metoksi-4-hidroksibenzaldehidin trietilaminli ortamda p-nitrobenzoil klorür ile reaksiyonundan elde edilen 3-metoksi-4-(p-nitrobenzoksi)-benzaldehid (2) ile reaksiyonundan sentezlenmiştir. Sentezlenen yeni bileşikler IR, 1H NMR ve 13C NMR spektrum verileri kullanılarak karakterize edilmiştir. Çalışmada, ayrıca, yeni bileşiklerin in vitro antibakteriyal etkinlikleri altı bakteriye karşı agar kuyucuk yöntemi ile belirlenmiştir. İn vitro ortamda sentezlenen yeni bileşiklerin antioksidan aktiviteleri üç farklı yöntemle tayin edilmiştir.
In this study, nine novel 3-alkyl-4-[3-methoxy-4-(p-nitrobenzoxy)-benzylideneamino]-4,5-dihydro-1H-1,2,4-triazol-5-ones (3) were synthesized from the reactions of 3-alkyl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (1) with 3-methoxy-4-(p-nitrobenzoxy)-benzaldehyde (2), which was synthesized by the reaction of 3-methoxy-4-hydroxybenzaldehyde with p-nitrobenzoyl chloride by using triethylamine. The structures of novel compounds were established from IR, 1H NMR and 13C NMR spectral data. In addition, in vitro antibacterial capacities of the new compounds were determined against six bacteria by mains of agar well diffusion method. Furthermore, newly synthesized compounds antioxidant capacities were performed by three different methods.
Field : Fen Bilimleri ve Matematik; Mühendislik
Journal Type : Ulusal
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