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  Citation Number 2
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Composition characterization and biological activity study of Thymbra spicata l. var. spicata essential oil
2021
Journal:  
Cumhuriyet Science Journal
Author:  
Abstract:

The current research aimed to determine and report in vitro antioxidant, antimicrobial, antibiofilm, cytotoxic, anti-cholinesterase, and anti-diabetic properties and the stability of the major component of basic oil of Thymbra spicata var. spicata through different phases as theoretically. Essential oil exhibits potential biological activities because of the multiple components it contains.In the current research, the evaluation of Thymbra spicata essential oil antioxidant properties was conducted utilizing 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2-azinobis[3-ethylbenzthiazoline]-6-sulfonic acid (ABTS) radical scavenging activity.Antimicrobial activity was assessed from minimum inhibition concentration (MIC) using the technique of microdilution and cytotoxicity activity was evaluated by MTT assay through MCF-7 and PC3 human cancer cell lines.Consequently, Cytotoxic activity was evaluated by means of MTT assay utilized. The essential oil was detected to have 340 µg/mL inhibiting influence on the growth of PC3 prostate cancer cells with IC50 value. Also, the T. spicata plant was observed to significantly repress the enzymes, namely acetylcholinesterase (AChE), butyrylcholinesterase (BChE), α-glycosidase. IC50 values of enzymes were obtained 0.23 µg/mL for AChE, 1.64 µg/mL for BChE, 7.78 µg/mL for α-glycosidase. It was concluded that this plant may be used for Alzheimer's and diabetes disease.

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2021
Author:  
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Cumhuriyet Science Journal

Field :   Fen Bilimleri ve Matematik; Mühendislik

Journal Type :   Uluslararası

Metrics
Article : 1.227
Cite : 634
2023 Impact : 0.077
Cumhuriyet Science Journal