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Abstract: Objective: To evaluate the optical coherence tomography (OCT) parameters in patients with nonartheritic ischemic optic neuropathy (NAION) and glaucomatous optic atrophy. Material-Method: Datas of patients diagnosed with glaucomatous optic atrophy (Group 1) and NAION (Group 2) and followed-up at the the glaucoma department between 2017-2020 were retrospectively analyzed. Detailed ophthalmologic examination including demographic data, best corrected visual acuity (BCVA), intraocular pressure (IOP), central corneal thickness (CCT) obtained by ultrasonic pachymetry, retinal nerve fiber layer (RNFL) and ganglion cell complex thickness obtained by OCT (Carl Zeiss Meditec, Dublin, CA, USA). The mean and regional (superior, superotemporal, inferior, inferotemporal, temporal, nasal, superonasal, and inferonasal) RNFL and ganglion cell complex thicknesses were compared between the groups. Results: The mean age of 30 patients (14 female and 16 male) in Group 1 was 66.2 ± 12 and the mean age of 36 patients (20 male, 16 female) in Group 2 was 61.6 ± 13.05 years. Age and gender were similar between the groups (p=0.25). The mean BCVA was 0.43 ± 0.3 and 0.16 ± 0.1 in groups, respectively (p <0.01). The mean RNFL was 50.8 ± 10 µ in Group 1 and 59.05 ± 11 µ in Group 2 (p:021). The mean ganglion cell thickness was 50.2 ± 10.4 and 48 ± 15 µ in Group 1 and Group 2, respectively. It was found to be significantly thinner in Group 2 (p:0.04). The mean inferior quadrant RNFL thickness was 53.96 ± 13 and 74.18 ± 23 µ, in Group 1 and Group 2, respectively and it was significantly thinner in Group 1 (p: 0.02). There was no significant difference between the two groups in the other quadrants’ RNFL thickness. The mean inferotemporal quadrant ganglion cell thickness was significantly thinner in Group 1 and the mean superoquadrant ganglion cell thickness was significantly thinner in Group 2 (p1 <0.01, p2:0.09). Discussion: The mean ganglion cell complex thickness was found to be thinner in the NAION group. This may indicate that the ganglion cell complex is more susceptible to ischemia-related damage.

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