Özet:

INTRODUCTION: We aimed to evaluate the clinical, metabolic, and endocrinological findings of adolescent girls with polycystic ovarian syndrome. METHODS: The data about menstrual patterns, physical examination (anthropometric measurements, Ferriman Gallwey score, acanthosis nigricans), basal/stimulated adrenal androgens, fasting glucose/insulin, lipid/lipoprotein levels, and ultrasonography findings were obtained from the medical records of 53 cases diagnosed according to Rotterdam criteria between January 2008 and December 2012. Patients with body mass index (BMI) percentile ≥95% according to age were defined as obese. Patients meeting all of the 3 criteria (menstrual irregularity, hyperandrogenism and polycystic ovaries on ultrasound) were defined as the classical group and the rest as the other group. The blood triglyceride level more than 97% percentile level according to age is considered high; insulin resistance was considered to be present in patients with HOMA-IR ≥3.82. The average age was 15±1.5 years. The most common complaint was menstrual irregularity (49.1%); oligo/amenorrhea was present in 60.4% of cases when questioned in detail. Acanthosis nigricans were more frequent in obese cases (p=0.010). Moderate-severe hirsutism (Ferriman Gallwey score ≥16) was present in 41.5% of patients in whom oligo/amenorrhea was more frequent (p=0.007). Insulin resistance was detected in 39. 6% of the patients (81% obese) and more frequent in patients with acanthosis nigricans (p=0.001). Hypertriglyceridemia was determined in seven of 49 cases in which insulin resistance was significantly more frequent (p=0.033). A positive correlation was detected between triglyceride and HOMA-IR levels (r: 0,415). Polycystic ovary on ultrasound was detected in 96.2% of patients. In classical group; oligo/amenorrhea, hirsutism, acanthosis nigricans, and hypertriglyceridemia were more frequent than the other group (p<0.005). The total testosterone level was higher in the classical group but the difference was not significant (p=0.056). The menstrual cycle of patients with polycystic ovarian syndrome should be questioned in detail. In patients with acanthosis nigricans, insulin resistance must be considered and in the presence of insulin resistance hypertriglyceridemia should be investigated.

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