Özet:

Purpose: The aim of this study was to compare thiol/disulphide haemostasis levels between healthy volunteers and the patients who were admitted to emergency with the complaint of ST Elevation myocardial infarction (STEMI). Materials and Methods: This case-control study was carried out in the Department of Emergency Medicine. The participants consisted of 48 healthy volunteers and 48 hospitalized patients with STEMI. The thiol / disulphide level was evaluated in each study group. The association of Thiol levels (native/total) was evaluated in patients with STEMI. Results: No significant difference was found between the patients with STEMI and healthy volunteers regarding their age or gender. The disulphide (SS) levels were similar in both groups. The total thiol (TT) and native thiol (SH) levels were much lower and the SS/TT levels were much higher in the patients with STEMI when compared with the volunteers.  Conclusion: This study revealed that the oxidant/antioxidant ratio was shifted to the oxidative side in patients with STEMI. An abnormal thiol/disulphide state might be considered as an important factor in the pathogenesis and in monitoring the treatment response. The thiol resources may be used for diagnosis of STEMI.