Abstract:

Vitamin B12 and folic acid deficiency lead to morphologically indistinguishable megaloblastic anemia may cause neuro-psychiatric syndromes by similar neuropathological mechanisms. Vitamin B12 and folic acid have indispensable roles in the structure of the central nervous system in all age groups. Vitamin B12 deficiency is seen in children with malnutrition, in children of mothers who are strict vegetarians or with pernicious anemia. Folic acid deficiency can occur as a result of malabsorption or dietary deficiency. Megaloblastic anemia; most common in children between the ages of 6 months and 2 years, and is expected to rarely develop after the age of 5. Most of school children with megaloblastic anemia have a history of chronic diarrhea, intestinal malabsorption syndrome or surgical surgery. This article will focus specifically on that, vitamin B12 deficiency or folic acid deficiency can cause neurological signs without megaloblastic anemia. One other reality, if there is no anemia or hematological findings, neurological signs are more levels. Neurological signs are inversely correlated with hematological findings. How severe one, the other can be so mild. According to previous knowledge, folic acid without vitamin B12 only corrects hematological findings, but folic acid treatment will delay the diagnosis and treatment of neurological disorders with vitamin B12 deficiency. However, in recent years, the administration of folic acid is as toxic to the neurological system in the situation of vitamin B12 deficiency, suggesting that the authors have drawn attention to another dimension of the event.

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