Özet:

Aim: This study evaluates whether the preoperative aspartate aminotransaminase/ alanine aminotransaminase (De Ritis Ratio - DRR) value affects the prognosis and has a relationship with histopathological variables of non-metastatic clear cell renal cell carcinoma (ccRCC) cases surgically treated. The second aim was to assess the association between neutrophil-lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and lymphocyte monocyte ratio (LMR) values with prognosis, and progression-free survival (PFS) in the same group of patients. Materials and Methods: We reviewed the medical records of 118 non-metastatic ccRCC cases that underwent partial or radical nephrectomy (2009-2019). Kaplan-Meier analysis with log-rank tests was performed to evaluate the difference in progression between DRR, NLR, PLR, and LMR and groups. Moreover, univariate and multiple Cox proportional hazard analyses were performed to identify the predictors of progression. Results: Metastases and local recurrence were detected in 22.9% and 6% of the patients, respectively. Our median follow-up period was 26 months. The univariate Cox regression analysis was showed that the tumor size, invasion (presence), pathological stage (3+4), and NLR level (≥ 1.98)) were statistically significant predictors for PFS. However, DRR was no statistically significant predictor for PFS (p>.05). Conclusion: We did not find any significant value for the DRR value as a predictive parameter in ccRCC prognosis. The increase in NLR is associated with a poor prognosis. Therefore, the use of NLR in predictive nomograms may contribute positively to the determination of prognosis.

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