Özet:

Langerhans cell histiyosytosis is a rare disease characterized by the clonal reproduction of the active Langerhans cells, which originates from histiyosytes and pathogenesis is unknown. This disease, which is seen with many different clinical presentations, is mostly found in the childhood age group. The largerhans cell histiyositosis, which most often shows bone, bone marrow and second often also skin stagnation, is divided into four subgroups according to the locations of stagnation and clinical presentations; Letterer-Siwe disease, Hand-Schüller-Christian disease, eozinofilic granuloma and congenital Self-Healing reticulohistiyositosis.  The exact diagnosis is placed by the electron microscopic display of the largerhans cell or by the surface antigen of CD1a immunochemically. In this article, a long-term treatment with seborrheic dermatitis diagnosis is presented with the phenomenon of long-term cell histiyositosis.