Abstract:

The aim of this study was to examine the genotoxic effects of ZnOTiO2 NPs using chromosome aberration (CA) and micronucleus (MN) tests in human peripheral lymphocytes. Cells were treated to ZnOTiO2 NPs concentrations in the range of 12.5 to 125 µg/mL for 24 and 48 hours. In addition, it induced structural CA at all concentrations with ZnOTiO2 NPs treatment. However, nanoparticles did not stimulate CA in a dose-dependent manner for 24 and 48 hours of treatment, and there were no statistically significant differences between both the administration time and the concentrations (P > 0.05). The formation of MN induced by ZnOTiO2 NPs increased depending on concentration and dose. In particular, the highest 2 concentrations (100 and 125 µg/ml) were observed to be significantly increased during the 24 and 48 hour treatment period (P > 0.05). Again, there is no significant difference in the occurrence of MN depending on gender (P > 0.05).

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