Abstract:

INTRODUCTION: The determination of predictive factors for neoadjuvant chemoradiotherapy response in locally advanced rectum cancer is critical concerning treatment management. We aim to analyze the predictive value of clinicopathologic findings of locally advanced rectal cancer patients before neoadjuvant chemoradiotherapy. METHODS: Fifty patients who were diagnosed with locally advanced rectum cancer without distant metastasis and underwent surgery after the neoadjuvant CRT treatment in department of general surgery, between January 2008 -2015 were analyzed. RESULTS: Twenty three (46%) of the cases did not respond pathologically, while 27 (54%) responded to neoadjuvant chemoradiotherapy. There was no statistically significant difference between the responding group and the non-responding group in terms of age averages and gender distribution (p = 0,360, p = 0,665), the distribution of tumor distance from anal verge (p = 0,777), pathologic types distribution (p = 0.451), pre-op T stage and N stage (p = 0.322 and p = 0.321), type of surgical procedures (p = 0,061, p = 0,200), CEA level (p = 0.195), and PLR level (p = 0.704). The possiblity of not responding to NLR> 4 cases was statistically significant (95% Confidence Interval: 2,043 - 62,915) compared to NLR <4 cases. (p = 0.005). DISCUSSION AND CONCLUSION: NLR can be used as a predictive factor in locally advanced rectal cancer before neoadjuvant chemoradiotherapy.

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