Study of drug–excipient interactions is a crucial step in preformulation stage of drug development to achieve consistent chemical, physical, bioavailability, manufacturability and stability of the dosage form. In pre-formulation studies, it is important to use thermoanalytical and spectroscopic methods. These are important systems for achieving a suitable formulation. Sildenafil is a well-tolerated and highly effective treatment for erectile dysfunction. erectile dysfunction was revolutionized with the development of a selective inhibitor of cyclic guanosine monophosphate-specific phosphodiesterase type 5. , Fourier Transform Infrared Spectroscopy, and X-ray Powder Diffraction systems were used in the investigation and to determine the possible interactions between sildenafil and some excipients like butylated hydroxyanisole, cellulose, sodium carboxymethyl cellulose, ascorbic acid, and citric acid. Binary mixtures of drug:excipient=1:1 (mass/mass) have been analyzed. According to the results, there is incompatibility with butylated hydroxyanisole, ascorbic acid, and citric acid.
Field : Fen Bilimleri ve Matematik; Mühendislik
Journal Type : Uluslararası
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