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Yapılan araştırmalarda demir eksikliği anemisi (DEA)’nin HbA1c düzeylerine etkisi tam olarak aydınlatılamamıştır. Muhtemel nedenler arasında hemoglobinin kuarterner yapısındaki değişimler ve β globin zincirindeki glukasyonun DEA hastalarında kolaylaşmış olması ihtimali üzerinde durulmaktadır. Çalışmamızda diyabetik olmayan premenopozal kadınlarda DEA’nin HbA1c düzeyine olan etkisinin araştırılması planlanmıştır. Çalışmamıza merkezimiz iç hastalıkları polikliniğine başvuran 18-46 yaş arası premenopozal 91 hasta dahil edildi. Bu bireylerden hemoglobin değeri 12 mg/dl altında olan 45 birey hasta grup, hemoglobin değeri 12 mg/dl ve üzerinde olan sağlıklı 46 birey ise kontrol grubu olarak sınıflandırıldı. Çalışmaya alınan grupların hemogram ve diğer demir parametrelerinin (demir, demir bağlama kapasitesi, total demir bağlama kapasitesi, ferritin, transferrin satürasyonu) HbA1c ile arasındaki ilişki araştırıldı. Çalışmamıza dahil edilen hastaların yaş ortalaması DEA’si olan grupta 32±10 yıl, kontrol grubunda ise 30±8 yıl idi. Demir eksikliği anemisi olan grubun serum HbA1c düzeyi, kontrol grubunun serum HbA1c düzeyinden yüksek olarak bulundu (sırasıyla 5.6±0.2 ve 5.1±0.2, p<0.001). Çalışmamızda HbA1c düzeyi DEA olan grupta istatiksel olarak anlamlı yüksek saptanmıştır. Çalışmamız sonucunda HbA1c düzeyleri yorumlanırken DEA ve diğer olası hata kaynakları konusuna dikkat edilmesi gerektiği kanaatine varılmıştır. DEA’nin etkin tedavisinin aneminin olumsuz etkilerini ve HbA1c yorumlanmasında oluşacak hataları ortadan kaldıracağı düşünülmektedir.
The effects of iron deficiency anemia (DEA) on HbA1c levels have not been fully revealed. Possible causes include changes in the quarterner structure of hemoglobin and the possibility that glucose in the beta globin chain has been facilitated in DEA patients. Our study is planned to investigate the effect of DEA on HbA1c levels in non-diabetic premenopausal women. Our study included 91 premenopausal patients aged 18-46 who appeared to our center for internal diseases clinic. 45 patients with a hemoglobin value below 12 mg/dl, 46 healthy individuals with a hemoglobin value below 12 mg/dl and 46 healthy individuals with a hemoglobin value below 12 mg/dl were classified as the control group. The relationship between the hemogram and other iron parameters of the groups involved ( iron, iron bonding capacity, total iron bonding capacity, ferritin, transferrin saturation) and HbA1c was studied. The average age of the patients involved in our study was 32±10 years in the group with DEA and 30±8 years in the control group. The serum HbA1c level in the group with iron deficiency anemia was found higher than the serum HbA1c level in the control group (respectively; 5.6±0.2 and 5.1±0.2, p<0.001). In our study, the HbA1c level was statically significantly high in the DEA group. The results of our study have found that the HbA1c levels should be interpreted while considering the DEA and other possible error sources. It is believed that effective treatment of DEA will eliminate the negative effects of anemia and errors in interpretation of HbA1c.
The effects of iron deficiency anemia (IDA) on HbA1c levels have not been elucidated. Possible causes include changes in the quaternary structure of hemoglobin and the possibility of facilitating glucose in the β globin chain in the patients with IDA. In our study, it was planned to investigate the effect of IDA on HbA1c in non-diabetic individuals. Ninety-five premenopausal patients aged between 18-46 years who were admitted to our outpatient clinic were included in our study. Forty-five patients with hemoglobin value below 12 mg/dl were classified as patient group and forty-six healthy subjects with hemoglobin value upper 12 mg/dl were classified as control group. The relationship between the hemogram and other iron parameters (iron, total iron binding capacity, ferritin, transferrin saturation) of the study groups were investigated. The mean age of the patients included in our study was 32±10 years in the patient group and 30 ± 8 years in the control group. The HbA1c level was %5.6±0.2 in the IDA group and %5.1±0.2 in the control group.HbA1c level of the control group was The difference between the groups was statistically significant (p <0.001). In our study, HbA1c level was significantly higher in the group with IDA. As a result of our study, it was concluded that IDA and other possible sources of error should be considered when interpreting HbA1c levels. It is thought that effective treatment of RIA will eliminate the negative effects of anemia and the errors that will occur in the interpretation of HbA1c.
Alan : Sağlık Bilimleri
Dergi Türü : Ulusal
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