Özet:

Melatonin is a potent antioxidant agent produced by the pineal gland. In this study we aimed to investigate the neuro-protective effect of melatonin on ischemic spinal cord in the rats. Aortic clamp was used for the occlusion of the abdominal aorta for 30 minutes. Twenty four Winstar male rats were used for this study and rats were divided randomly into 4 groups: control group (sham group, n: 5), sham+melatonin treated group (receiving 10mg/kg melatonin intraperitoneally, n: 5), ischemia/reperfusion group (undergoing occlusion but receiving no pharmacologic intervention, n: 7), melatonin + ischemia/reperfusion group (undergoing occlusion and receiving 10mg/kg melatonin intraperitoneally 10 minutes after ischemia, n: 7). Spinal cord samples were taken for the malondialdehyde (MDA) analyses. In the aort occlusion group, the MDA levels, indicating the extend of lipid peroxidation, were significantly higher than the other groups (p<0.05). Also in the aort occlusion + melatonin group the levels of MDA was significantly reduced compared to the aort occlusion group (p<0.05). In this study, we showed that injection of melatonin reduces the effects of secondary injury and facilitate the recovery of the damaged spinal cord.

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