Özet:

It was aimed to evaluate the central analgesic activity of 0.3, 1 and 3 mg/kg (p.o.) rosmarinic acid in mice by hot- plate and tail-immersion tests in a time dependent manner and the peripheral analgesic activity by acetic acid-induced writhing-test. Furthermore one of the other purpose of the study is to research the involvement of serotonergic and noradrenergic modulation on rosmarinic acid-induced analgesia by using 1 mg/kg (i.p.) ketanserin, 5HT2A/2C receptor antagonist, and yohimbine, α2-adrenoceptor antagonist, respectively. The enhanced withdrawal responses to thermal stimuli were observed 45 minutes after the administration of 1 mg/kg rosmarinic acid; 30, 45 and 60 minutes after the administration of 3 mg/kg rosmarinic acid in hot-plate test; 45 and 60 minutes after the administration of 1 and 3 mg/kg rosmarinic acid in tail-immersion test. In writhing-test, the number of writhing significantly decreased 45 minutes after the administration of 0.3, 1 and 3 mg/kg rosmarinic acid. Rosmarinic acid-induced antinociception was significantly reversed by ketanserin only in tail-immersion test while it was reversed significantly in both tail-immersion and writhing-test by yohimbine. Rosmarinic acid provides analgesic effects by modulating serotonergic and noradrenergic systems that are located in descending inhibitory pathway and by stimulating peripheral noradrenergic system. Therefore, rosmarinic acid is a natural agent that can be used safely as a co-adjuvant in pain management

Anahtar Kelimeler: