Abstract:

The relationship between angiogenesis and hyperexpression of COX-2 in various tumors has been studied. In our study, COX-2 expression in pancreatic ductal adenocarcinoma, and micro vessel density was investigated in relation to each other and with various clinicopathological parameters. Materials and Methods: There are sixty one cases diagnosed with pancreas immunoperoxidase staining technique was applied to sections belonging to the cases, using primary polyclonal antibodies developed against the CD31 protein and primary polyclonal antibodies developed against the COX-2 protein. Microvessels marked with CD31 antibodies were numerically evaluated by the stereological method described by Barth and his colleagues in their studies. The relationship between COX-2 expression, microvessel density and the clinicopathological parameters were also evaluated. Evidence: COX-2 expression was shown in 73.8% of the cases. No correlation was detected between rates of COX-2 receptor staining, vessel parameters, standard prognostic parameters and survival. Conclusion: Although COX-2 expression was tracked in most cases diagnosed with pancreatic ductal adenocarcinoma, no significant association was found between COX-2 and angiogenesis, and it was thought that hyperexpression of COX-2 does not have an impact on the prognosis, considering the clinicopathological factors

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