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Antileishmanial screening, physicochemical properties and drug likeness of pyrazole carbaldehyde derivatives
2015
Journal:  
Asian Pacific Journal of Health Sciences
Author:  
DOI:  
10.21276/apjhs.2015.2.2.8
Abstract:

Antileishmanial activities of the five pyrazole derivatives were evaluated in vitro on a culture of Leishmania donovani promastigotes (Strain S1). The results for Antileishmanial activity were compared with the standard drug Amphotericin B. Compound three and four were found to possess good activity than the standard drug. All the compounds were characterized by various spectroscopic techniques such as IR, 1H-NMR, 13C-NMR etc. Physicochemical properties and bioactivity score studies were carried out using Lipinski’s rule of five, Molinspiration (web based software). The results of computational studies found in accordance with the results obtained experimentally.

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Asian Pacific Journal of Health Sciences

Field :   Sağlık Bilimleri

Journal Type :   Uluslararası

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Asian Pacific Journal of Health Sciences