Abstract:

Aim: In recent years, it has been seen that simple complete blood count (CBC) parameters can be used to show subclinical inflammation in patients with familial Mediterranean fever (FMF). The aim of this study is to determine whether there is a difference in CBC parameters among FMF patient groups divided according to disease severity scores. Material and Methods: FMF patients followed up in our clinic between 2016 and 2019, were reviewed for medical records. They were divided into three groups as those with mild, moderate, and severe diseases according to the disease severity scoring systems by Pras et al., Mor et al., and International Severity Score of FMF (ISSF). Red cell distribution width (RDW), platelet, neutrophil, lymphocyte, RDW-platelet ratio (RPR), platelet-lymphocyte ratio (PLR), and neutrophil-lymphocyte ratio (NLR) of the patients were compared among the groups. Results: According to the scoring system of Pras et al., lymphocyte value was found significantly higher in the group with severe disease compared to the groups with mild and moderate diseases (p=0.031). PLR was significantly lower in the group with severe disease compared to moderate diseases according to the scoring system of Mor et al (p=0.008). According to ISSF, there was no difference among the groups in terms of CBC parameters. Conclusion: Different results were obtained according to all three scoring systems. Since the ISSF is the most common and suitable system for use in FMF patients, we can conclude that there is no relationship between disease severity and RDW, RPR, NLR and PLR.

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