Abstract:

Breast cancer (BC) and Thyroid Papillary Cancer (TPC) are known to be the two most common types of cancer in women. It is known that the development of TPC in patients with BC is increased compared to the normal population. However, studies on the evaluation of increased risk in this regard are limited. Within the scope of the current study, it was aimed to evaluate the risk factors of TPC development in patients diagnosed with BC. The data of patients who were operated for TPC between 2006 and 2018 were retrospectively compiled from the endocrine surgery database. Twenty-three patients with a previous diagnosis of BC and undergoing thyroidectomy for TPC were included in the study group. The same number of patients who had no history of other malignancies and who had undergone surgery for TPC constituted the control group. The two groups were compared in terms of family history, demographic data, laboratory values, surgical characteristics and disease stage. The mean age of the 46 patients evaluated in the study was 55.35±9.2. The median time to diagnosis of TPC after BC was 27 (0-275) months. There was no statistically significant difference between the two groups in terms of age, body mass index, and menstrual status, presence of hyperthyroidism and positivity of autoantibodies. Family history positivity was statistically significantly different in the MC+TPC group compared to the TPC group (p=0.0023). It was observed that there was no significant difference between the two groups in terms of demographic data, laboratory values, surgical characteristics and disease stage in terms of increased risk. However, especially patients with a family history of BC and ovarian cancer should be followed closely for the development of TPC.

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