Özet:

Civanperchemy (CP) is widely used in alternative medicine and in its structure, along with many compounds, there is also Luteolin. In this study, the effects of CP methanol extract and Luteolin on the isolated rat muscle flat contractability were studied. In the study, 20 male Sprague Dawley rates were used and the rates were decapitated under anesthesia. The isolated meshmas were cleaned and the muscle stripes prepared from the meshmas were hanged in the organ bath. 1 gram of it was applied and left for an incubation period of 1 hour. At the end of the incubation period, the CP extract was applied to the bathroom in the framework of a protocol of Luteolin, Acetylcholine (ACh), Potassium Chloride (KCl) and Nifedipin. The data was one way evaluated by the Tukey test in ANOVA. CP extract and different doses of Luteolin have been found to inhibit isolated mesh contractions induced by ACh and KCl. The contractions caused by the submaximum dose of ACh were found to be stronger pressed with CP extract and Luteolin in the presence of Nifedipin in the bathroom. The infections induced by the submaximum dose of KCl were found to be more inhibited by Nifedipin with CP extract, but the effect of Luteolin in the presence of Nifedipin in the bath was not found to change. The study found that CP extract and different doses of Luteolin inhibit the mesh flat muscle contractions and are effective through CP extract and Luteolin's L type Ca2+ channels, while CP extract could also be effective through the M3 receptor pathway.

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