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Giriş: Östrojen progesteron ve c-erbB2 ekspresyonu negatif olan üçlü negatif meme kanserleri, diğer meme kanser türlerine göre daha kötü prognoza sahiptir. Bu çalışmada üçlü negatif meme kanserlerinin klinik demografik ve patolojik karakteristikleri ve bu karakteristiklerin genel sağkalım ve progresyonsuz sağkalımla olan ilişkisi retrospektif olarak incelenerek prognostik faktörler, kemoterapi etkinlikleri ve sağkalım oranları ile sağkalıma etki eden faktörlerin belirlenmesi amaçlanmıştır. Yöntem: Başkent Üniversitesi Hastanesinde 1997-2009 arasında takipli üçlü negatif meme kanserli hasta retrospektif olarak incelendi. Bulgular: Hastaların median yaşları 49 idi. Median takip süresi 27 ay idi (0.27-132 ay). İki hasta takip sırasında ex oldu. 38 hastada invaziv duktal karsinom, üç hastada invaziv lobuler karsinom, beş hastada meduller karsinom saptandı. Hastaların neredeyse yarısında lenf nodu invazyonu vardı. %79 hastanın T2 hastalığı vardı. Hastaların %30 unun tümör histolojik derece III, ve neredeyse yarısında evre II hastalık vardı. %95 inde ailede kanser öyküsü mevcuttu. Adjuvan kemoterapi 43 hastaya verildi. 15 hastada relaps gözlendi. En sık metastaz akciğere idi. Yüksek dereceli tümörü olan, üçden fazla lenf nodu tutulan, ve genç yaşta olanların takiplerde daha fazla relaps olduğu görüldü. Tartışma: Literatürle uyumlu bir şekilde, bizim üçlü negatif meme kanserli hastalarımız da agresif karakteristikliydi. Median takip süresi kısa olmasına rağmen üçlü negatif meme kanserli hastaların doğasını destekleyecek şekilde ¼ hastada rekürrens izlendi. Çalışmamızda hastalarımız daha genç yaşta tanı almış, yüksek dereceli tümörlü ve visseral organlara metastaz yapma eğilimleri daha fazla idi.
Introduction: Three-negative breast cancer with estrogen progesterone and c-erbB2 expression negative has a worse prognosis than other types of breast cancer. In this study, the clinical demographic and pathological characteristics of triple negative breast cancers and the relationship of these characteristics with overall survival and progressive survival are studied retrospectively, with the aim of determining prognostic factors, chemotherapy effects and survival rates and the factors affecting survival. Method: In the Capital University Hospital between 1997-2009 followed triple negative breast cancer patients were retrospective examined. The patient’s average age was 49. The median tracking period was 27 months (0.27-132 months). Two patients were followed by the ex. In 38 patients, invasive ductal carcinoma, in three patients, invasive lobular carcinoma, and in five patients, medular carcinoma were detected. Nearly half of the patients had lymphatic nod invasion. 79 percent of patients had T2 disease. 30% of patients had a tumor of histological degree III, and almost half of them had a stage II disease. 95% of the family had a history of cancer. Adjuvan chemotherapy was given to 43 patients. 15 patients were recurred. The most common metastasis was the lungs. With a high degree of tumor, more than three lymphatic nodes have been held, and young people have seen more recurrence in their followings. Discussions: In accordance with literature, our three-negative breast cancer patients were also aggressive. Although the median follow-up period was short, recurrence was monitored in 1⁄4 patients in order to support the nature of patients with triple negative breast cancer. In our study, our patients were diagnosed in a younger age, with a higher degree of tumor and a higher tendency to metastases to the viral organs.
Aim: Triple negative breast cancer in which estrogen, progesterone receptors and c-erbB2 overexpression are negative, seems to have different clinical course and recurrence pattern. We retrospectively evaluated clinical demographic and pathological characteristics of triple negative breast cancers and investigated the association of these characteristics with OS and PFS, and also we aimed to identify prognostic factors, chemotherapy effects, survival rates, and the factors that effect survival rates. Method : 59 patients with triple negative breast cancer patients followed in Başkent University Hospital between 1997-2009 were evoluated retrospectively. Results : The median age of patients was 49. Median follow-up duration was 27 months (0.27-132 months). Two patients died during the follow-up. Invasive ductal carcinoma pathology was reported in 38 patients, invasive lobular in 3 patients, medullary in 5 patients. Almost half of the patients had LVI. 79% of patients had a T2 disease. 30% of patients’ tumor histological grade was III. Cancer history in the family was present in 95% of patients. Almost half of the patients had stage II disease. Adjuvant chemotherapy was given to 43 patients. Relapses were observed in 15 patients.The most common metastatic site was lung. Patients having high grade tumor, >3 (+) lymph nodes, younger age have higher chance of relapse during follow-up. Conclusions: In accordance with the literature, our triple negative breast cancer patients showed more aggressive characteristics. Although median follow-up is short, one-fourth of the patients having recurrence support natue of the triple negative breast cancer patients. In our study, triple negative patients had younger age at diagnosis, high grade tumors and more tendency to metastasize to visceral organs.
Field : Sağlık Bilimleri
Journal Type : Ulusal
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