Abstract:

Ganglioneuroma is a well differentiated neoplasia of sympathetic nervous system. It is rare in the adrenal gland. The most common sites of involvement are the posterior mediastinum and retroperitoneum. These tumors though benign, can very rarely metastasize to regional lymph nodes. They are usually clinically silent and detected during exploration of other unrelated conditions. Histopathology is the only tool to diagnose ganglioneuroma and to differentiate it from ganglioneuroblastoma and neuroblastoma.We present an adult case with ganglioneuroma in her left adrenal. Histopathological examination showed that the tumoral lesion was a ganglioneuroma composed of both mature ganglion cells and Schwannian stroma arising in the adrenal gland. The paraaortic lymph node showed the same tumoral tissue. In conclusion, ganglioneuroma occurs rarely in adrenal gland and pre-operative diagnosis is difficult. Histopathological examination is the crucial step of diagnosis.

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