AMAÇ: Bu çalışmanın amacı sistemik sağlık üzerinde etkisi kanıtlanmış olan periodontal durumun infertil kadınlarda uygulanan in vitro fertilizasyon tedavisi sonuçları üzerindeki etkisini değerlendirmektir. GEREÇ VE YÖNTEM: İnfertilite tanısı konmuş kadın hastalardan sosyodemografik veriler bir anket yardımıyla toplanmıştır. Kan testi gününde plak indeksi, gingival indeks, cep derinliği, sondalamada kanama indeksi ölçümleri yapılmıştır. Buna göre sağlıklı, gingivitisli ve periodontitisli olarak sınıflandırılan hastalar ile kullanılan human chorionic hormon gonadotropin (hCG) dozu, östradiol ve progesteron seviyeleri, transfer edilen embriyo sayıları, oosit sayıları ve gebelik sonuçları karşılaştırılmıştır. Çalışmada, tek yönlü ANOVA, Tukey HDS, Tampane’s T2, Kruskal-Wallis, Mann-Whitney U ve ki-kare testleri kullanılmıştır. BULGULAR: Gruplar arasında oosit sayıları, transfer edilen embriyo sayıları ve gebelik sonuçları açısından bir farklılık gözlenmemiştir. Gruplar arasında hCG günü östradiol seviyesi açısından bir farklılık gözlenmemesine karşın hCG günü progesteron seviyesi periodontitis grubunda sağlıklı ve gingivitisli gruba göre anlamlı şekilde yüksek bulunmuştur. SONUÇ: Periodontitis grubunda gözlenen progesteron seviyesindeki yükselme IVF sonucunu etkileyebilecek olan eşik değerin altındadır. Periodontal durumun infertilite tedavisi üzerindeki etki mekanizmasının belirlenmesi için geniş ölçekli ve uzun vadeli çalışmalara ihtiyaç duyulmaktadır.
The aim of this study is to evaluate the effects of periodontal condition, which has been proven to have an effect on the systemic health, on the results of in vitro fertilization therapy applied in infertile women. WORK AND METHOD: Infertility diagnosed female patients have sociodemographic data collected with the help of an survey. On the day of the blood test, the plaque index, gingival index, cell depth, and the endemic bleeding index were measured. Accordingly; the dose of human chorionic hormone gonadotropin (hCG) used to healthy, gingivitis and periodontitis classified patients, the levels of estradiol and progesterone, the number of transmitted embryos, the number of oocytes and the result of pregnancy were compared. In the study, one-way ANOVA, Tukey HDS, Tampane's T2, Kruskal-Wallis, Mann-Whitney U and Ki-Care tests were used. There is no difference between the groups in the number of oocytes, the number of embryos transferred and the result of pregnancy. Although there was no difference in the levels of estradiol on hCG day between the groups, the levels of progesterone on hCG day were significantly high in the periodontitis group compared to the healthy and gingivitis group. The increase in progesterone levels observed in the periodontitis group is below the margin that could affect the IVF result. Large and long-term studies are required to determine the mechanism of effect on the treatment of infertility of the periodontal condition.
OBJECTIVE: This study aims to evaluate the effect of periodontal status, which has been proven to have effects on systemic health, on the outcomes of in vitro fertilization (IVF) treatment which is applied to infertile women. MATERIAL AND METHODS: Sociodemographic data have been collected from female patients diagnosed with infertility through a questionnaire. On the day of the blood test, plaque index, gingival index, probing depth and bleeding index on probing were measured. Recruited patients were classified into the healthy, gingivitis, and periodontitis groups according to the aforementioned criteria. These groups were compared with respect to human chorionic gonadotropin (hCG) dosage, estradiol and progesterone levels, the number of oocyte and embryos transferred, and pregnancy outcomes. One-way ANOVA, Tukey HDS, Tampane’s T2, Kruskal-Wallis, Mann-Whitney U, and chi-square tests were used in this study. RESULTS: The three groups were statistically similar in the aspect of retrieved oocytes, transferred embryos and pregnancy outcomes. Although three groups had statistically similar in terms of estradiol levels on the day of hCG administration, progesterone levels were significantly higher in the periodontitis group compared to healthy and gingivitis groups. CONCLUSIONS: This elevation in progesterone levels observed in the periodontitis group is below the threshold level which could affect the IVF outcomes. Large scale and long-term studies are needed to clarify the effects of periodontal status on IVF outcomes.
Alan : Sağlık Bilimleri
Dergi Türü : Ulusal
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