Abstract:

ABSTRACT Objective: The purpose of this study was to evaluate the levels of salivary malondyaldehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GP-x) levels in patients with periodontal disease and hyperlipidemia. Method: One hundred and twenty three subjects with hyperlipidemia aged 30 to 57 and 68 systemically healthy controls (C) aged 31 to 54 were included in the study. Hyperlipidemic groups were divided into two groups as suggested diet (HD) and prescribed statin (HS). All of the groups were divided into three subgroups as healthy (h), gingivitis (g) and periodontitis (p). The clinical periodontal parameters, including plaque index (PI), gingival index (GI), probing pocket (PPD) depth, percentage of bleeding on probing (BOP-%), and clinical attachment level (CAL) were recorded. Serum lipids and salivary MDA, SOD, GSH and GP-x levels were evaluated. Results: MDA is significantly and positively correlated with GI, BOP-% and the ratio of total cholesterol/high density lipoprotein in both hyperlipidemic groups. In the HSh group, salivary SOD level was higher than in the HSp group. Discussion: The salivary MDA and SOD levels are parameters which may play role in the association between periodontal disease and hyperlipidemia. Further longitudinal studies in larger populations with different periodontitis and hyperlipidemia phases are needed to clarify this association. Key words: Gingivitis; periodontitis; hyperlipidemia; malondyaldehyde; superoxide dismutase; glutathione; glutathione peroxidase.

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