Özet:

INTRODUCTION: Safe and effective drugs are still lacking for many pain therapies. In recent years, growing interest has been devoted thus on herbal drugs as an option to identify new pain killers. Based on this, extensive researches are carried out on Verbascum L. genus due to its therapeutic potency on pain and inflammation therapy. Among them, we investigated the antinociceptive effect of Verbascum exuberans Hub.-Mor, and its contributions to nitrergic, serotonergic and opioidergic pathways as well as its antiinflammatory acitivity. METHODS: Tail clip, tail flick, and hot plate tests were used to determine the central (spinal and supraspinal), while acetic acid-induced writhing test was measured for the peripheral antinociceptive effect of the extract (250 and 500 mg/kg). Nω-Nitro-L arginine methyl ester, cyproheptadine, and naloxone were combined with the extract (250 mg/kg) to assess the involvement of nitrergic, serotonergic, or opioidergic pathways, respectively. Carrageenan-induced hind paw edema model was used to assess the antiinflammatory effect of the extract (250 mg/kg). RESULTS: The extract presents central spinal but not central supraspinal antinociceptive effect and shows peripheral antinociceptive effect. The antinociceptive actions of the extract is largely regulated via targeting the nitrergic pathway, while the opioidergic pathway is partly involved. Further, the extract shows antiinflammatory effect due to the significant inhibitions on the time dependent edema progression and the cytokine (TNF-α and IL-1β) productions. DISCUSSION and CONCLUSION: We suggest that V. exuberans could be a new source with a high beneficial potential in alleviating pain and inflammation.

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