Özet:

In this work, 15 different coumarin hydrazides were successfully synthesized and screened for their antioxidant and antilipase activities. To do this, firstly, salicylaldehyde derivatives and 2,2-dimethyl-1,3-dioxane-4,6-dione (Meldrum's Acid) were reacted in ethanol in the presence  of catalytic amount of pyridine to obtain coumarin-3-carboxylic acid derivatives (1a-e). Then, these compounds were treated with benzotriazole in dichloromethane by using thionyl chloride to synthesized benzotriazole derivatives (2a-e). Then, compounds 2a-e were reacted with three commercial hydrazides (nicotinic hydrazide, benzhydrazide and phenylacetichydrazide) in ethanol by using microwave irradiation and conventional heating procedures to obtain final products (3-5a-e). Finally, these compounds were tested for their anti-oxidant and anti-pancreatic lipase activities. The structure of newly synthesized compounds was identified by 1H NMR, 13C NMR and elemental analysis data.

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