Abstract:

Aim: Periampullary region adenocarcinomas, which includes pancreatic ductal adenocarcinoma and ampullary carcinoma is one of the malignant tumors with characterized by rapid metastatic progression and resistant to medical and surgical treatments. Heat shock genes are activated by heat shock factor-1 and facilitates malignant transformation and cancer cell proliferation.  P53 is a tumor suppressor gene which mutated in more than 50% of pancreatic cancers. In this study, the relation of paramaters which include tumor size, lymph node metastasis, tumor stage, tumor grade and prognosis with HSF-1 and P53 expession was analysed. Material and Methods: 69 pancreaticoduodenectomy materials which performed in the Istanbul Education and Research Hospital were researched entirely about the HSF-1/ P53 expression, age, gender, tumor location, tumor size, tumor stage, tumor grade, presence of lymph node metastasis and prognosis. Results: In our study, tumors which stained  >10%, had more percentage in large tumor size, advanced stage tumors, high grade tumors, positive lymph nodes and poor prognosis. Conclusion: Our study suggest that HSF-1 and P53 expression plays role at carcinogenesis of especially high grade periampullary region adenocarcinomas. In addition, these two markers may be preferred in combination with other parameters, at the diagnosis of poor differentiated adenocarcinomas.                                       

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