Abstract:

OBJECTIVES: Cigarette smoking has multiple different effects on thyroid function. However, there is no literature data whether acute one dose cigarette smoking effect on the thyroid hormone and antibody levels. The aim of this study was to effect of one dose smoking on serum free triiodothyronine (fT3), free thyroxine (fT4), thyrotropin (TSH) and thyroid autoantibody levels in euthyroid patient population. MATERIALS and METHODS: We studied 31 euthyroid patients, 24 women and 7 men. Of these patients, 21 were ex-smokers, and 10 were non-smokers. Serum fT3, fT4, TSH and thyroid autoantibody levels were examined pre- and post-one dose cigarette smoking in each patient. RESULTS: Between ex-smokers and non-smokers groups, thyroid hormone and autoantibodies levels were not effect one dose smoking significantly (p>0.5). In ex-smokers, antithyroid peroxidase antiboy were higher than in non-smokers, and there was significant difference between ex-and non-smokers in pre- or post-smoking (p<0.04). In ex-smokers, antithyroid peroxidase antibody was significantly different after single dose smoking (p<0.01). But in ex-and non-smokers, there was no significant difference antithyroglobulin antibody at pre-and post-smoking (p>0.5). CONCLUSION: The association between smoking and thyroid abnormalities is controversial. (i) Significant higher antithyroid peroxidase antiboy with normal levels of antithyroglobulin antibody in ex-smokers concluded that smoking habit increase tendency of autoimmune thyroid disease. Therefore this elevation point out that there was no destruction in thyroid tissue yet. (ii) On the other hand, our findings concluded that one dose cigarette smoking was not effect on thyroid hormone and autoantibody levels.

Keywords: