Abstract:

Purpose: Previous studies have shown that idiopatic hypogonadotropic hypogonadism (IHH) patients with low testosterone levels lead to an impaired glucose metabolism, and an increased cardiovascular risk.  Monocyte to high-density lipoprotein cholesterol (HDL-C) ratio (MHR) also has been shown to be an indicator of inflammation and cardiovascular risk.  The purpose of the present study is to investigate MHR in the male with IHH.  Material and Methods: This study includes 31 men with IHH without previous treatment for the disease and 44 healthy men.  The blood sampling, anthropometric measures, and physical examination were undertaken by all the participants. Results: Mean ages of the IHH patients and the healty controls were 22.5±7.2 years vs. 22.9±6.4 years.  There was no statistically significant difference between the patients and controls in terms of the mean HDL-C, mean monocyte count, and mean MHR.  The MHR also was not correlated with the other hematological parameters, inflammatory parameters, and the total testosterone level. Conclusion: MHR has been shown to be an indicator of cardiovascular risk in previous studies but we could not detect an increased MHR value in patients with IHH In this study.

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