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Amaç: Kronik spontan ürtiker (KSÜ), düşük yaşam kalitesi ile seyreden, kronik, yaygın ve zorlayıcı bir hastalıktır. Bu çalışmanın temel amacı, KSÜ hastalarında, Kronik Yaygın Ağrının (KYA) varlığını araştırmak ve KYA ile KSÜ arasında klinik özellikler, laboratuvar belirteçler, hastalık aktivite skorları ile dermatoloji yaşam kalitesi indeksi (DYKİ) arasındaki olası bağlantıyı ortaya koymaktır. Yöntem: KSÜ' lü 91 hasta, KYA varlığı açısından üçüncü basamak polikliniğinde değerlendirildi. KSÜ’lü hastalarda, KYA (en az üç ay boyunca dört kadran ve aksiyel olmak üzere beş vücut bölgesinden dördünde veya daha fazlasında ağrı) varlığı romatoloji polikliniğinde değerlendirildi. Ayrıca, hastaların anti-nükleer antikor (ANA), eritrosit sedimantasyon hızı, CRP (C-reaktif protein), B12, total IgE ve anti-TPO test sonuçları da analiz edildi. Hastalar hastalığın başlangıcı ve süresi, eşlik eden morbiditeleri, anjioödem varlığı, atopi öyküsü ve uykudan uyandıran gece kaşıntısı yönüyle değerlendirildi. Hastaların hastalık aktivitesini ortaya koymak için ürtiker kontrol testi (UKT), ürtiker aktivite skoru (UAS) ve hekim ve hastaların genel sağlık durumunu ayrı ayrı değerlendirdiği görsel analog skala kullanıldı. Ayrıca, hastaların yaşam kalitesi dermatolojik hastalık yaşam kalite indeksi (DYKİ) ile değerlendirildi. Sonuç: KSÜ’lü 91 hastadan 23'ünde (25.3%) KYA mevcuttu. KYA +, KSÜ' lü hastalarda anlamlı yüksek Doktor Global değerlendirme skoru (p=0.003), Hasta global değerlendirme skoru (p=0.005), UAS (p=0.046), DYKİ (p<0.001) ve düşük UCT skorları bulundu. KYA’lı 23 hastanın dokuzunda, eşlik eden hastalık olarak astım (39.1%) bulundu (p=0.005). Tartışma Ürtiker hastalarında KYA'nın varlığı, hastaların yaşam kalitesini ve hastalık skorlarını olumsuz yönde etkileyebilir.
Background and aims Chronic spontaneous urticaria (CSU) is a chronic, common and debilitating disease and associated with severely impaired quality of life (QoL). The main objectives of this study are to explore the presence of Chronic Widespread Pain (CWP) in patients with CSU and to reveal the possible associations between CWP and CSU on the clinical features, laboratory markers and urticaria activity scores with QoL. Methods We assessed the 91 patients with CSU for CWP in a tertiary outpatient clinic. Pain in four or more out of five bodily regions. the four quadrants and axially for at least three months) was assessed in a rheumatology outpatient clinic in patients with CSU. We also analyzed the test results of anti-nuclear antibodies (ANA), blood sedimentation rate, CRP (C-reactive protein), B12, total IgE, and anti-TPO. Patients were assessed for their onset and duration of disease, comorbidities, occurrence of angioedema and history of atopy, and night pruritus with disturbed sleep. Patients disease activity was assessed by the urticaria control test (UCT), urticaria activity score (UAS) and visual analog scale of the physician and patient's global assessment. Furthermore, patients completed a questionnaire to assess the quality of life (QoL) for dermatological diseases. Results Of the 91 patients with CSU assessed for CWP, 23 (25.3%) were positive. CWP + and patients with CSU had significantly higher physician global assessment score (p=0. 003), Patients global assessment score (p=0.005), UAS (p=0.046), dermatologic QoL (p<0.001) and lower UCT (p=0.005) scores. Nine of 23 CWP + and patients had asthma (39.1%) as a comorbidity (p=0.008). Conclusions The presence of CWP in patients with urticaria may have a negative impact on the quality of life of the patients and disease scores.
Background and aims Chronic spontaneous urticaria (CSU) is a chronic, common and debilitating disease and associated with severely impaired quality of life (QoL). The main aims of this study are to explore the presence of Chronic Widespread Pain (CWP) in patients with CSU and to reveal the possible associations between CWP and CSU on the clinical features, laboratory markers and urticaria activity scores with QoL. Methods We assessed the 91 patients with CSU for CWP in a tertiary outpatient clinic. CWP (pain in four or more out of five bodily regions, i.e. the four quadrants and axially at least for three months) was assessed in a rheumatology outpatient clinic in patients with CSU. We also analyzed the test results of anti-nuclear antibody (ANA), blood sedimentation rate, CRP (C-reactive protein), B12, total IgE, and anti-TPO. Patients were assessed for their onset and duration of disease, comorbidities, occurrence of angioedema and history of atopy, and nocturnal pruritus with disturbed sleep. Patients disease activity were assessed by the urticaria control test (UCT), urticaria activity score (UAS) and visual analog scale of physician and patient’s global assessment. Furthermore, patients completed a questionnaire to assess the quality of life (QoL) for dermatologic diseases. Results Of the 91 patients with CSU assessed for CWP, 23 (25.3%) were positive. CWP +ve patients with CSU had significantly higher physician global assessment score (p=0.003), Patients global assessment score (p=0.005), UAS (p=0.046), dermatologic QoL (p<0.001) and lower UCT (p=0.005) scores. Nine of 23 CWP +ve patients had asthma (39.1%) as a comorbidity (p=0.008). Conclusions The presence of CWP in patients with urticaria may have a negative impact on the quality of life of the patients and disease scores.
Field : Sağlık Bilimleri
Journal Type : Uluslararası
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