Özet:

Purpose: Natural compounds (especially those that can be eaten) obtained from plants have therapeutic/preventive effects on certain disorders, such as cancer and gastrointestinal disorders. The main purpose of the study is Eremurus (E) spectabilis M. Bieb. The extracts are to study the inhibitor effects on histon deacetylase (HDAC), xanthin oxidase (XO) and urethrase activities. Tools and Methods: The fresh leaves of E. spectabilis are supplied from a local market in Ayup/Istanbul. The inhibitor activities of ethanol and ethyl acetate extract on HDAC, XO and urethrase have been studied. Results: According to the results obtained, E. It has been found that both ethanol and ethyl acetate extracts of spectabilis have a clear inhibitor effect on all the enzymes studied. Ethanol extract has shown a better inhibitory effect than ethyl acetate extract on HDAC. Ethyl acetate extract has been shown to have a higher inhibitor effect against both XO and urethra than ethanol extract. Result: As a result, due to the inhibitor effects shown by the study plant, it can be suggested that this plant can be used for medical purposes, in the form of raw extra or as a bioactive compound source.

Anahtar Kelimeler:

Özet:

Objective: Natural ingredients derived from plants (especially ed-ible ones) continue to be investigated for understanding whether they have therapeutic/preventive effects on certain ailments, such as cancer and gastrointestinal disorders. The main goal of the current work is to investigate the inhibitory potential of Eremurus (E) spectabilis M. Bieb. extracts on histone deacetylase (HDAC), xanthine oxidase (XO) and urease activities. Material and Method: Fresh E. spectabilis leaves were obtained from a local market in Eyup/Istanbul. Inhibitory activities of ethanolic and ethyl acetate extracts on HDAC, XO and urease were examined. Results: According to our findings, ethanolic and ethyl acetate extracts of E. spectabilis both have revealed apparent inhibitory effects against all examined enzymes. Ethanolic extract showed a better inhibitory effect on HDAC than ethyl acetate extract. On the other hand, the inhibitory effects of ethyl acetate extract against both XO and urease were higher than the ethanolic extract. Conclusion: Consequently, due to the inhibitory effects of the plant being studied, it might be suggested that it can be used for medicinal purposes, in raw extract form, or as a source of bioactive compounds.