Abstract:

Introduction: The aim of our study is to compare different types of insulin in type 2 diabetic patients who are frequently receiving interim insulin treatment in terms of daily insulin dose needs and therapeutic success, to identify the causes of treatment failure despite high doses Method: Retrospective designed our study included 198 type 2 diabetic patients under basal bolus insulin treatment. Patients were divided into 3 groups according to the types of insulin they received (Group 1: Short and long-effective analog insulin fields(n: 83) , Group 2: Short and long-effective regular insulin fields(n: 58) , Group 3: Regular insulin + long-effective analog insulin fields(n: 57) ) Patient tracking files recorded demographic data and daily insulin dose information. These data and the reach rates to the target level HbA1c were compared between groups. In addition, insulin doses were compared to patients who could and could not reach glycemic targets. 123 of 198 patients (62.1%) are female and 65 (47.9%) are male. The average age of the three groups is 55,81±8,1, 58,3±8,9, 58,3±8,8 respectively. HbA1c levels were 8.72 ± 1.65, 9.02 ± 1.98, and 9.05 ± 2.24 in Group 1. The target value A1c is below 7% in the analog treatment group is 27.7%, in the regular treatment group is 25.9%, and in the regular + analog treatment group is 31.6% (p > 0.05). The daily bolus and basal insulin doses of the three groups, the total and kg insulin doses and the basal bolus ratio did not differ significantly (p > 0,05). In Group 1 and Group 2, the total daily insulin doses were significantly higher in patients who were unable to the target of glycemic control, while in Group 3 the basal insulin doses were significantly higher than in patients who were unable to the target. In our study we did not find a clear difference in dosage analyses between analog and regular insulin, the most important result was that high insulin dosages may not be sufficient for glycemic control. These patients should be searched for the underlying cause, the causes that can be corrected should be eliminated. (SETB 2018-10-140)

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