Özet:

Introduction-Aim: Familial Mediterranean Fever (FMF) is a periodic inflammatory disease characterized by recurrent febrile attacks and polyserositis; inherited in an autosomal recessive manner. Recent studies confirmed that chronic subclinic inflammation is frequently present between febrile episodes in patients with FMF, although FMF patients are usually clinically asymptomatic. The aim of the present study was to investigate the effects of FMF on bone metabolism in children with FMF. Material-Methods: Thirty five prepubertal FMF patients in attack free period who were receiving regular colchicine therapy and 30 healthy children with similar age and gender were included in this study as study and control groups. All patients’ physical examination was performed and all data about symptoms at admission and positive findings in their physical examination were recorded. Additionally, biochemical parameters, bone turnover markers, bone age, and bone mineral density (BMD) obtained at lumbar 1-4 levels were evaluated for each patient. Findings: There was no statistically significant difference between height, weight, bone age, and BMD values of study and control groups (p>0.05). There was a positive correlation between vitamin D level and mean BMD values obtained at L1-L4 levels (p: 0.024, r: 0.38). A regression in bone age according to the chronologic age was detected in 5 (14%) and BMD Z scores lower than -2 SDS was detected in 2 (5%) FMF patients. Conclusions: BMD and bone turnover markers of children with FMF receiving regular colchicine therapy didn’t differ from those of healthy children. Bone age regression and low BMD Z scores in some FMF patients may be the secondary effects of subclinical inflammation

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