Özet:

OBJECTIVE: To investigate the effect of topically administered vitamin A on break up time (BUT), corneal staining score and ocular surface disease index (OSDI) in dry eye patients. MATERIALS AND METHODS: Thirty eyes of 15 patients were included in the study. Topical Vitamin A (Vit-A Pos pomad) twice a day was administered for 2 months to the semptomatic dry eye patients who have not undergone any ocular surgery, who have not got any additional ocular surface disease and who have an OSDI score of >25. BUT values, corneal staging scores with Oxford grading scale and OSDI scores after the treatment were compared with the values before the treatment. RESULTS: Mean age of the patients was 54.26±12.89. The means of BUT, corneal staining and OSDI scores before the treatment were 2.26±0.59, 2.53±0.74 and 45±13.82, respectively. After 2 mo Vitamin A treatment, patients’ complaints decreased, the means of BUT, corneal staining and OSDI scores after the treatment were found to be 2.93±1.22, 2.06±0.79 and 29.66±12.53, respectively. When compared the values before and after the treatment, differences were seen to be statically significant. P values were 0.027, 0.029 and <0.01 for BUT, corneal staining and OSDI scores, respectively. None of the patients complained about adverse effect. CONCLUSION: Vitamin A treatment was seen to reduce the complaints of dry eye patients. It was resulted in a significant decresae in especially OSDI and corneal staining scores, also a significant increase in BUT value. Vitamin A provides a symptomatic improvement in dry eye patients and should be considered as an alternative treatment in symptomatic dry eye patients.

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