Özet:

The current research was accomplished to assess analgesic and anti-inflammatory activities in Limnophila repens (L.repen) methanolic extracts at 200 and 400 mg/kg. The entire herb was extracted with the methanol (MELR). Acute oral toxicity of the extract was according to OECD-423 recommendations. Analgesic activity was explored by utilizing hot plate, tail immersion and acetic acid-evoked writhing models. Anti-inflammatory activity (acute) of the extract was assessed by carrageenan evoked paw edema model. In acute toxicity study, no mortality was observed when each extract was orally administered with 2000 mg/kg. At the doses (200 and 400 mg/kg) MELR demonstrated considerable and dose reliant analgesic and anti-inflammatory effects. The conclusions from the present investigation confirmed the folkloric usage of Limnophila repens as analgesic and antiinflammatory. This significant anti-inflammatory and analgesic impact might be because of the inhibition of any inflammatory mediators by steroids, i.e., ß-sitosterol, stigmasterol, flavonoids, i.e. quercetin and glycosides within the extract. But, further phytochemical, as well as biological tests, are needed to determine the additional active chemical constituents responsible for the antinociceptive and anti-inflammatory activities.

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