Özet:

Due to various pathological problems caused by excessive alcohol use, it is a global problem nowadays. Studies done shows that; Excessive alcohol consumption can cause disbiotic changes in the intestinal microbiota. Recent studies have shown that microbiota plays a key role in the development of many diseases, especially gastrointestinal microbiota. Chronic alcohol use causes an increase in intestinal over permeability by disrupting the intestinal barrier through increased oxidative stress loading in the intestine. This increased intestinal over permeability allows the passage of proinflammatory/pathogenic microbial products such as endotoxin through the intestinal lumen to the liver via the portal vein. Exposure to these bacterial products may cause inflammation in the liver. Although human and animal studies on the effects of chronic alcohol use on intestinal microbiota are extremely rare, they provide important data. Further studies in the future will be able to better understand the effects on alcohol intestinal microbiota. In this review, the effects of alcohol consumption on the microbiota of the gastrointestinal tract will be examined.

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