Abstract:

Objective This study aims to evaluate the effects of prognostic factors depending on gender and the factors affecting survival in women patients who underwent resection for non-small cell lung cancer (NSCLC). Material and Methods Patients who underwent lung resection due to NSCLC in our hospital between January 2007 and December 2018 were included in the study. 1491 patients were included in the study. Results The mean age of the patients was 60.0±8.41 (range: 26-84) years. There were 1324 (88.8%) male patients and 167 (11.2%) female patients. Pneumonectomy was performed in 406 (27.2%) patients, lobectomy in 1077 (72.2%) patients, and segmentectomy in 8 patients (0.5%). The mean 5-year survival time was 57.5%. In the study, the 5-year survival rate of female patients was 66.8%, while it was 56.4% in males (p=0.005). When the pN2 status was evaluated, the 5-year survival rate was 34.3%, while the survival rate was 64.1% in patients with pN0 (p<0.001). The most important prognostic factors affecting survival in Cox regression analysis were gender, advanced age, wider resection, pN2, and advanced stage. When the factors affecting survival in female patients were evaluated in the subgroup analysis, the 5-year survival rate was 32.9% in patients aged 65 and over (p<0.001). When the histopathology was evaluated, the 5-year survival rate was 67.1% in adenocarcinomas, while 70.7% in squamous cell cancers. Conclusion As a result of our study, the main histopathological cell type seen in female patients is adenocarcinoma. Especially in women, advanced age, large cell cancers, advanced stage, and pN2 status are poor prognostic factors in survival.

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