Özet:

Purpose: This study aimed to assess the relationship between S100β protein with neurological deficit and mortality within 1 week in patients with Intracerebral hemorrhage (ICH) stroke. And also, to determine the relationship between hematoma volume with S100β protein. Patients and Methods: a prospective observational cohort study. Patients with sampling from consecutive admission from August 2016 to December 2017 were performed head CT Scan, met inclusion and exclusion criteria. Neurological deficits as ascertained with National Institute of Health Stroke Scale (NIHSS). Blood samples were taken at the admission to the hospital and on the 7th day of onset. Results: There were 46 patients with 25 men (54.3%) and 42 controls with a median age of 56 (31- 76) and 34.5 (21-67) years. The most risk factor was hypertension (78,3%). Median onset of acute ICH stroke was 8.5 (0.5-48) hours. Median level of consciousness according to Glasgow Coma Scale (GCS) at the admission to the hospital was 14 (3-15) and the NIHSS was 11.50 (0-37). Serum S100β protein levels correlated significantly with NIHSS (r=0.418;p=0.004). Area Under Curve (AUC) of S100β was 0.839±0.103 (95% CI, 0.638-1.000), cutoff level was 28,505 pg/mL with 80% sensitivity and 87.8% specificity (p=0.014). Serum S100β protein levels associated significantly with mortality within 1 week (p=0.032). The hematoma volume correlated with S100β protein levels (r=0.678;p<0.001). Conclusion: S100β protein was significant correlation with neurological deficits. S100β protein was associated significantly with mortality within 1 week. The hematoma volume was significant correlation with S100β protein.

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