Özet:

Objective: Depression is a common chronic recurrent psychiatric disorder, characterised by clusters of symptoms affecting many different systems. Due to complexity of the pathogenesis and differences in response to treatment, current therapies are incapable of providing an exact recovery, leading to attempts to investigate new treatment options. In many studies, it is shown that pyrazoline derivatives have the therapeutic potential as antidepressant agents. In this study, we aimed to investigate the antidepressant-like profile of a series of new 2-pyrazoline derivatives. Methods: Antidepressant-like activity was evaluated by using tail suspension test, which was followed by forced swim test for those compounds found effective in tail suspension test in Balb/c mice.The behavioural parameter observed in both tests was immobility period, which is an indicative of antidepressant-like effect. Results: Test compounds 3d and 3e were effective and a significant reduction in immobility time was observed when compared to results of imipramin, as the reference drug. Additionally, these two compounds did not alter the locomotor activity in mice. Conclusion: Our results indicate that two 2-pyrazoline derivatives, 3d and 3e, are potential compounds for use in designing of new candidates for the treatment of depression.

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