Abstract:

In clinics staying immunocompromised patients, it is important to determine the risk factors for the colonization of carbapenem resistant gram negative bacteria (CRGNB). The aim of this study was to determine the risk factors of CRGNB colonization in hospitalized patients in bone marrow transplantation (BMT) unit and to find out the effect on infection development of the colonization. This study was performed on patients over 18 years, taken routinely rectal swab samples weekly, and hospitalized in BMT units. Identification of CRGNB was performed in the Microbiology Laboratory. Every patient was enrolled in the study once. A total of 125 patients were enrolled in the study. The average age of patients was 49 years and 56.8% of them were male. CRGNB colonization was detected in 18 patients (14.4%) from rectal swab sample. The factors affecting the colonization with CRGNB were defined as transfer from a hospital, previous intensive care unit (ICU) admission, respiratory failure and bronchoscopy procedure in multivariate logistic regression analysis. The transfer from a hospital was found out as the lowest effective factor, stay in ICU increased development of the colonization 47.39 times, respiratory failure 63.21 times, and bronchoscopy procedure 9.16 times. Moreover, 27.7% of colonized patients gave rise to a systemic infection. Knowing the frequency of CRGNB colonization and the risk factors of colonization is important for starting early and appropriate empirical treatment. Surveillance of CRGNB colonization in the BMT unit can be useful in hospitals having sufficient support.

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