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Amaç: Bu çalışmada genel cerrahi kliniğimizde meme cerrahisi yapılan hastalarda histopatolojik sonucu duktal karsinoma in situ (DKİS) gelen hastalarımızın cerrahi yöntem ve sistemik tedavi sonuçlarını, rekürens ve mortalite oranlarını değerlendirmeyi amaçladık . Yöntem: Ocak 2016 ile Ocak 2021 tarihleri arasında, genel cerrahi kliniğiniğimizde meme cerrahisi geçiren tüm hastaların preoperatif ve postoperatif histopatolojik sonuçları incelendi. Histopatolojik sonucu DKİS gelen hastaların demografik verileri, klinikopatolojik özellikleri, reoperasyon sayısı, postoperatif radyoterapi (RT), anti-östrojen hormon tedavisi (HT), lokal rekürens (LR) oranı, ve genel sağkalım (GS) oranı hastanemiz veri datasından ve ulusal ölüm bildirim sisteminden retrospektif olarak incelendi. Bulgular: Çalışma grubu histopaptolojk sonucu DKİS gelen toplam 24 kadın hastadan oluşmakta idi. Grubun ortalama yaşı 49,96 ± 10,61’dir. Lezyonların meme içinde yerleşiminde, 11 (45,8%) ‘ i tek odaklı, 7 (%29,2) ‘si multifocal ve 6 (%25)’ sı ise multisentrik olarak gözlenmiştir. En sık uygulanan operasyon tipi lumpektomidir (n=16, 66,7%). 8 hastaya sentinel lenf nodu biyopsisi yapılmıştır. Ortanca tümör boyutu 12,5 (4-70) mm’dir. En sık görülen moleküler tip Luminal A’ dır (n=14, 58,3%). Lezyona en yakın cerrahi sınır uzaklığı ortanca 5 (0-20) mm’dir. Hastaların cerrahi sonrası ortalama takip süresi 32,20 ± 18,22 aydır. Hastaların 87,5%’si (n=21) operasyon sonrası HT ve 58,3%’ü (n=14) RT almıştır. Hastaların hiçbirinde nüks gelişmemiştir ve mortalite gözlenmedi. Sonuç: Genel cerrahi kliniğimiz olarak multidisipliner yaklaşım ve iyi bir preoperatif evreleme ile DKİS hastalarına en uygun cerrahi yöntemi ve risk faktörlerini de değerlendirerek uygun hastalarda meme koruyucu cerrahi sonrası RT ve Östrojen reseptörü+ hastalarda HT ‘ yi öneriyoruz.
Purpose: In this study we aimed at evaluating the surgical method and systemic treatment results of our patients from the histopathological result of duktal carcinoma in situ (DKIS) in our general surgical clinic, recurrence and mortality rates. Method: Between January 2016 and January 2021, the preoperative and postoperative histopathological results of all patients who have been undergoing breast surgery were studied in our general surgical clinic. The demographic data of patients from the histopathological result, clinic pathological characteristics, the number of reoperations, postoperative radiotherapy (RT), anti-estrogen hormone therapy (HT), local recurence (LR) and general survival (GS) ratio were examined retrospectively from our hospital data and the national death reporting system. Results: The study group consisted of a total of 24 female patients from the DKIS as a result of histopaptology. The average age of the group is 49.96 ± 10.61. In the placement of lesions within the breast, 11 (45,8%) 's were monocentric, 7 (29,2) 's multifocal and 6 (25%) 's were multisentric. The most common type of operation is lumpectomy (n = 16, 66,7%). 8 patients were biopsyed with the lymphatic nodus. The average tumor size is 12.5 (4-70) mm. The most common molecular type is Luminal A (n=14, 58,3%). The surgical limit distance of the lesion is 5 (0-20) mm. The average follow-up period of patients after surgery is 32.20 ± 18.22 months. 87.5% of patients (n=21) received HT after surgery and 58.3% (n=14) received RT. None of the patients had no development and mortality was not observed. Result: As our general surgical clinic, with a multidisciplinary approach and a good preoperative evolution, we also assess the appropriate surgical method and risk factors to the DKIS patients and recommend HT in the appropriate patients after breast protection surgery RT and estrogen receptor+ patients.
Objective: The aim of this study was to evaluate the surgical method and systemic treatment results, recurrence, and mortality rates in patients whose histopathological results were ductal carcinoma in situ (DCIS) following breast surgery in our general surgery clinic. Methods: A retrospective review was made of the preoperative and postoperative histopathological results of all patients who underwent breast surgery in our general surgery clinic between January 2016 and January 2021. The demographic data, clinicopathological features, postoperative systemic treatments, local recurrence (LR) rate, and overall survival (OS) rate of patients whose histopathological results were reported as DCIS were obtained from the data system of our hospital and the national death reporting system. Results: The study group consisted of 24 female patients with a histopathology result of DCIS. The average age of the patients was 49.96 ± 10.61 years. In the localization of the lesions in the breast, 11 (45.8%) were observed as unifocal, 7 (29.2%) as multifocal, and 6 (25%) as multicentric. The most common type of operation was lumpectomy (n = 16, 66.7%). Sentinel lymph node biopsy was performed in 8 patients. The mean follow-up period of the patients after surgery was 32.20 ± 18.22 months. Anti-estrogen hormone therapy (HT) was applied to 21 (87.5%) patients and radiotherapy (RT) to 14 (58.3%) after the operation. There was no recurrence in any of the patients and no mortality was observed. Conclusion: With a multidisciplinary approach and good preoperative staging, as applied in our general surgery clinic, it can be recommended that the most appropriate surgical method is applied, and risk factors determined for DCIS patients. RT is recommended for eligible patients after BCS and HT in estrogen receptor+ patients.
Field : Sağlık Bilimleri
Journal Type : Uluslararası
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