Özet:

Objective Polycythemia vera (PV) is a clonal disease characterized by clonal proliferation of myeloid cells. It has been shown that the Janus tyrosine kinase 2 (JAK2) gene V617F mutation forms the basis of the molecular pathogenesis of the disease. In this study, it was aimed to examine the relationship between JAK2 V617F mutation frequency and hematological parameters in patients with PV. Material and Methods A total of 78 patients, 18 female and 60 male, with PV were included in this retrospective cohort study. Demographic characteristics, laboratory findings and JAK2 V617F mutation analysis results were recorded by examining the outpatient clinic files of the patients. JAK2 V617F mutation analyzes were performed by Real-Time PCR method. Results JAK2 V617F mutation was detected in 21 (26.9%) of 78 PV patients included in the study. There was no difference between the presence of mutation and gender (p>0.05). In the grouping made according to mutation positivity, while age, RBC, RDW and PLT levels were found to be significantly higher in patients with JAK2 V617F mutation (respectively, p=0.000; p=0.030; p=0.028; p=0.029), serum iron level was found to be significantly lower. (p=0.036). WBC, HB and HCT levels were similar in both groups (p>0.05). Conclusion More comprehensive prospective studies are needed to demonstrate the prognostic value of the mutation and its relationship with clinical and laboratory variables.

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