Abstract:

Introduction: Diagnostic criteria of adenocarcinoma in needle biopsies and relation between these and tumour Materials and methods: Fifty five (55) adenocarcinoma cases in prostate needle biopsies were examined for prominent nucleoli, nuclear enlargement, mitosis, intraluminal eosinofilic secretion, basophilic mucin, amphophilic cytoplasm, intraluminal crystaloid, perineural invasion by the light microscope. The relation between diagnostic criteria and Gleason grading were studied. Results: The most frequent criteria were as follows: nuclear enlargement, prominent nucleoli and intraluminal eozinofilic secretion. Intraluminal crystalloid and basophilic mucin were seen occasionally. The relation between intraluminal crystalloid and Gleason grading has been defined as inversely proportional. The relation between the other criteria and Gleason grading has no statistical correlation. In our study we evaluated that perineural invasion, extra prostatic invasion and Gleason grading were prognostically important criteria. Conclusion: In order to define prostate adenocarcinoma all of cytomorphologic criteria should be evaluated and interpreted. We suggested that perineural invasion, extraprostatic invasion and Gleason grading should be expressed in the reports of needle biopsies which are important for staging, planning of treatment and prognosis

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