Abstract:

Aterosclerosis is very common in patients with diabetes mellitus (DM). We have studied whether there is a relationship between asymmetric dimethyl argin (ADMA) and atherosclerosis, known as the 'endogenic nitric oxide sentase inhibitor' in type 2 DM patients. Tools and Methods: Type 2 DM diagnosed with an average age of 55.73±8.78 years, a total of 85 patients (48.2 percent [n: 41] men) were included in the study. Laboratory parameters such as ADMA plasma levels, lipid profile, HbA1c were evaluated. The carotis intima-media thickness (IMT) was measured, an indicator of aterosclerosis. Patients were divided into two groups as high and low ADMA levels. Results: Statistically serum ADMA levels with total cholesterol (r=0.045; p=0.684), triglyceride (r=-0.067; p=0.544), LDL cholesterol (r=0.142; p=0. There is no significant relationship between HDL cholesterol (r=0.085; p=0.085) and HDL cholesterol (r=0.085; p=0.085). A statistically meaningful relationship was established between the ADMA level and HbA1c (r=0.376; p=0.001) and the serum ADMA level and the carotish-intimate media thickness (r=0.321; p=0.003). Result: Serum ADMA levels are associated with carotenoid IMT. The assessment of ADMA levels in type 2 DM patients may be useful in the prediction of aterosclerotic diseases such as coronary artery disease.

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