Abstract:

Aims: The purpose of this study is to evaluate the association between nutritional status and coronary artery disease (CAD) severity in patients with acute coronary syndrome (ACS). Methods: Patients with ACS who underwent coronary angiography were evaluated retrospectively. SYNTAX scores were calculated for each patient to determine the severity of CAD. The patients were divided into three groups based on their SYNTAX scores as low SYNTAX score (≤22), intermediate SYNTAX score (23-32) and high SYNTAX score (≥33). The Prognostic Nutritional Index (PNI) score was calculated with the formula using serum albumin and total lymphocyte count. The “The Control Nutritional Status (CONUT)” score was calculated by using three parameters which are serum albumin, total cholesterol and total lymphocyte count. Data on cardiovascular mortality and rehospitalization within six months of diagnosis were obtained from records. Results: The study included 177 patients with ACS. The mean age of patients was 63.34±10.94 years and 64.4% were male. Patients with high SYNTAX score had statistically significantly lower PNI score and higher CONUT score than patients with low and intermediate SYNTAX scores. There was a positive correlation between SYNTAX score and CONUT score (r=0.256, p=0.002), and a negative correlation between SYNTAX score and PNI score (r=-0.328, p<0.001). Within six months of ACS diagnosis, patients with cardiovascular mortality and rehospitalization had lower PNI scores and higher CONUT scores. According to multivariate logistic regression analysis, CONUT score was an independent predictor for high SYNTAX score (odds ratio=1.584; 95% confidence interval=1.014-2.473; p=0.043). Conclusions: In our study, nutritional status assessed by PNI and CONUT scores was associated with the extent of coronary atherosclerosis in patients with ACS.

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