Özet:

The high prevalence of childhood obesity and related serious health consequences have received increasing attention in medical studies and health policies. Obesity is recognized as a risk factor for cardiovascular disease. Oxidative stress is a risk factor for endothelial dysfunction in obese individuals. Therefore, we aim to evaluate paraoxonase 1 (PON1) activity with malondialdehyde (MDA) levels in obese children.Our study included 51 obese children and 40 healthy controls aged 6-15 years. Obesity was defined as a body mass index (BMI) ≥ 95th percentile for age and gender. While serum lipid profiles were analyzed by Siemens ADVIA 1800, PON1 activity and MDA were evaluated by spectrophotometric method. While triglycerides, total cholesterol and LDL-cholesterol levels were higher, HDL-cholesterol levels were lower in obese children than in controls (p < 0.05). On the other hand, we found that obese children had higher MDA levels and PON1 activities, but this was not significantly different in obese children. Although there is no significant difference between oxidant and antioxidant parameters in obese children compared with control children, because of dyslipidemia they are recognized as risk factors for cardiovascular disease. Lifestyle changes and entertaining physical activity should be implemented as necessary strategies in managing childhood obesity and dyslipidemia

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