Abstract:

Aim: Patients with acromegaly are at risk of metabolic diseases, such as diabetes mellitus, insulin resistance and hypertriglyceridemia. We aimed to investigate what is effective in the development of non-alcoholic fatty liver disease (NAFLD) in patients with acromegaly. Materials and Methods: 60 (33 female, 27 male) patients with acromegaly, and a healthy control group of 52 persons (27 female and 25 male) were retrospectively studied. Mean age of the patients and the control group were 44.11 ±13.83 and 39.12±14.99 respectively. Body mass index (BMI), liver ultrasound and laboratory findings were taken from the records in the files. Statistical analyzes were performed using SPSS statistical software package version 22 (IBM Corporation, USA). Results: Fasting blood sugar, triglyceride, insulin like growth factor, growth hormone(GH) and CRP levels were significantly higher, HDL levels were significantly lower in acromegaly group. BMI and NAFLD were similar between groups. We found that, BMI and GH are the most important two factors in the presence of NAFLD in patients with acromegaly. NAFLD correlates significantly positively with the patient's BMI, weight and age; significantly negatively with the GH levels. Conclusion: In people with acromegaly, BMI and GH levels are the things that affect development of NAFLD.