Özet:

Objective: Zinc (Zn) is an important trace element known to play a role in defense against viral infections as well as its immune response enhancing effect. In this study, it was aimed to determine Zn levels in COVID-19 cases followed in our clinic and to examine its relationship with routine laboratory parameters and disease severity. Method: One hundred thirty-five COVID-19 patients and 26 healthy individuals were included in the study. Serum Zn levels were measured by colorimetric method. In addition, creatinine, ALT, AST CK, LDH, ferritin, CRP, D-dimer and fibrinogen levels were evaluated. Results: Serum Zn levels in all patient groups compared to the control group it was found to be statistically significantly lower in the moderate, severe and critical patient groups compared to the mild patient group. In addition, while Zn levels showed a weak negative and significant correlation with creatinine, ALT, AST, CK, leukocyte levels, they showed a significant, moderate and negative correlation with age, CRP, ferritin, D-dimer and fibrinogen levels. Conclusion: Serum Zn levels are statistically significantly lower in COVID-19 patients than in healthy individuals. Although there was no clear relationship between the severity of the disease and serum Zn levels in COVID-19 cases, it was observed that there was a significant relationship between the biochemical and inflammatory markers associated with the severity of the disease and serum Zn levels.

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