Abstract:

Objective: The purpose of this study is to determine the sero-prevalence of anti-nuclearantibody (ANA), anti-straight muscle antibody (ASMA), liver kidney micro-chromosomal antibody– 1(LKM–1), anti-mitochondrial antibody M2 (AMA-M2), anti-thyro-globulin antibody (a-TG), anti-double stranded DNA (dsDNA), anti-single stranded DNA (ssDNA) and anti-SM antibodies in patients with chronic hepatitis B and C who were diagnosed with chronic hepatitis B and hepatitis C and had positive HBV DNA and HCV RNA, and compare these values between themselves and values obtained normal population. Material and Methods: 30 HBV DNA and 30 HCV RNA positive Chronic hepatitis B and C and 30 healthy control group serum samples. During the study, serums were melted at room temperature and then worked by ELISA method. Results: Hepatitis B patients; 3 involved ANA (10 %) , 10 ASMA (33,3 %), 1 LKM–1 (3,3 %), 16 AMA-M2 (53,3 %), 1 anti-TG (3,3 %), 3 anti-dsDNA (10 %), and 3 anti- ssDNA (10 %) Hepatitis C; 4 involved ANA (13,3 %), 14 ASMA (46,7 %), 2 LKM–1 (6,7 %), 12 AMA-M2 (40 %), 5 anti-TG (16,7 %), 4 antidsDNA (13,3 %), and 4 anti-ssDNA (13,3 %).In a group of 14 healthy patients; 2 involved ANA (6,7 %), 5 ASMA (16,7 %), 8 AMA-M2 (26,7 %), 3 anti-TG (10 % ), 2 anti-dsDNA (6,7 %), and 2 anti-ssDNA (6,7 %). Conclusion: This study of chronic hepatitis B and C showed that HBV and HCV induced autoantibody formation. ( Sakarya Med J 2017,7(2):79-84 ).

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