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Amaç: İzole koroner arter ektazisi (CAE), koroner arterin anormal genişlemesidir ve iskemiye neden olabilir. RDW, çeşitli kardiyovasküler bozukluklarda araştırılmıştır ve yakın zamanda,hastalarda olumsuz sonuçların öngörücü bir biyobelirteçi olabileceği öne sürülmüştür. Artmış RDW'nin,her ikisi de inflamasyonla ilişkili olduğu için, izole CAE ile de ilişkili olacağını varsaydık. Gereç ve Yöntemler: İzole CAE'li 69 hasta ve anjiyografik olarak normal 71 hasta olmak üzere 140 denek üzerinde çalışıldı. Temel klinik özellikler ve RDW dahil laboratuvar bulguları iki grup arasında karşılaştırıldı. Bulgular: RDW düzeyi izole CAE'de normal kontrollere göre anlamlı derecede yüksekti (14,36±1,61 'a 13,59±1,57, p=0,005). Ek olarak, izole CAE'de glomerüler filtrasyon hızı ve kreatinin, yüksek yoğunluklu lipoprotein ve düşük yoğunluklu lipoprotein seviyeleri normal kontrollere göre anlamlı derecede düşüktü (76,43±19,64'e karşı 100,36±18,3 ,0,9±0 ,28 'e karşı 0,74±0,25, 43,39±10,09'e karşı 48,4±13,67, 121,36±32,05 'e karşı 143,70±55,33 ,sırası ile p=0,001, p=0,001, p=0,01, p=0,004).ROC eğrisi analizinde, 13,5'lik bir RDW değeri, izole CAE'nin varlığının veya yokluğunun ayrımında etkili bir kesme noktası olarak tanımlandı ([AUC]: 0,71, CI %95, 0,62-0,80, p<0,001). Sonuç: Verilerimiz, RDW'nin izole CAE varlığını saptamak için yararlı bir belirteç olabileceğini göstermiştir
Isolated coronary artery extension (CAE) is an abnormal extension of the coronary artery and can cause ischemia. RDW has been studied in a variety of cardiovascular disorders and has recently been suggested that negative results in patients may be a predictive biological indicator. As increased RDW is associated with inflammation, we assumed that it would also be associated with isolated CAE. Tools and Methods: It studied over 140 patients with isolated CAE with 69 patients and angiographically normal 71 patients. Basic clinical characteristics and laboratory findings including RDW were compared between two groups. Results: RDW levels were significantly higher than normal controls in isolated CAE (14,36±1,61 to 13,59±1,57, p=0,005). In addition, the glomerular filtration rate and the levels of creatine, high-intensity lipoprotein and low-intensity lipoprotein in isolated CAE were significantly lower compared to normal controls (76,43±19,64 against 100,36±18,3 ,0,9±0 ,28 against 0,74±0,25, 43,39±10,09 against 48,4±13,67, 121,36±32,05 against 143,70±55,33 respectively p=0,001, p=0,001, p=0,01, p=0,004). Result: Our data has shown that RDW may be a useful indicator to determine the existence of isolated CAE
Aim: Isolated coronary artery ectasia (CAE) is an abnormal dilatation of the coronary artery which cause ischemia. RDW has been investigated in several cardiovascular disorders and has also been recently proposed as a predictive biomarker of adverse outcomes in patients with these conditions. We hypothesized that increased RDW would be associated with isolated CAE because both are associated with inflammation. Material and Methods: We studied 140 subjects, including 69 patients with isolated CAE, 71 patients with angiographically normal controls. Baseline clinical characteristics and laboratory findings, including RDW, were compared among two groups. Results: The level of RDW was significantly higher in isolated CAE than normal controls (14,36±1,61vs 13,59±1.57, p=0.005). In addition, the levels of glomerular filtration rate and creatinin, high density lipoprotein and low density lipoprotein were significantly lower in isolated CAE than normal controls (76,43±19,64 vs 100,36±18,3 and 0,9±0,28 vs 0,74±0,25, 43,39±10,09 vs 48,4±13,67, 121,36±32,05 vs 143,70±55,33 p=0,001, p=0,001, p=0,01, p=0,004 respectively). In a ROC curve analysis, a RDW value of 13,5 was identified as an effective cut off point for the discrimination of the presence or absence of isolated CAE (Area Under curve [AUC]: 0.71, CI 95%, 0.62-0.80, p<0,001). Conclusion: Our data suggested that RDW may be a useful marker to predict CAE
Alan : Sağlık Bilimleri
Dergi Türü : Uluslararası
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