Abstract:

Introduction: Mentha piperita is an aromatic herb in the mint family. It is  a hybrid mint that is a cross between spearmint and watermint. It can be found naturally in North America and Europe. Herbal extracts are rich in antioxidants which scavenges the free radicals produced as a result of metabolism in the body. Xanthine oxidase is an enzyme that is involved in purine metabolism, by generating uric acid. Aim: The aim of the study is to analyse antioxidant and antigout activity of ethanolic leaf extract of Mentha Piperita Linn. Materials and Methods: Methanolic leaf extract for mentha piperita was prepared. Antioxidant and Xanthine oxidase inhibitory potential of the extract was analysed by standard methods.The data were analyzed statistically by a one-way analysis of (ANOVA) followed by Duncan’s multiple range test was used to see the statistical significance among the group. The results with the p< 0.05 level were considered to be statistically significant.  Results: Phytochemical constituents like terpenoids, flavonoids, phenol, alkaloids, saponins and steroids were present in the extract. Antioxidant potential of the ethanolic extract was observed in a dose dependent manner. Xanthine oxidase inhibitory was maximum at 300 and 400 μg/ml of the ethanolic extract. Conclusion: To conclude the study, ethanolic extract of Mentha piperita possessed potent in vitro antioxidant and xanthine oxidase inhibitory activity.  

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